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Disease Severity and Progression

DISEASE STAGES OF COPD

Bronchiectasis severity is determined according to a combination of factors. There are two tools currently available to assess severity of bronchiectasis. These are the Bronchiectasis Severity Index (BSI) and the FACED.

The bronchiectasis severity index using a mix of clinical, radiological and microbiological features and is a strong predictor of morbidity and mortality for this condition. It also give excellent prediction for hospital admission and exacerbations.

The BSI uses the following criteria and is calculated using this Online Calculation Tool (https://www.bronchiectasisseverity.com/15-2/):

Criteria for BSIClassification of severity
BMI
% FEV1 predicted
0-4 Mild bronchiectasis
1 yr outcome: 0-3.4% hospitalization rate
4 yr outcome: 0-9.2% hospitalization rate
Previous hospital admission
Has the patient been hospitalized with a severe exacerbation in the past 2 years?
5-8 Moderate Bronchiectasis
1 yr outcome: 1.0-7.2% hospitalization rate
4 yr outcome: 9.9-19.4% hospitalization rate
Number of exacerbations in the previous year
mMRC Breathlessness Score
Pseudomonas colonization (chronic colonization is defined by the isolation of Pseudomonas aeruginosa in sputum culture on 2 or more occasions, at least 3 months apart in a 1-year period)
Radiological Severity
9+ Severe Bronchiectasis
1 yr outcome: 16.7-52.6% hospitalization rate
4 yr outcome: 41.2-80.4% hospitalization rate

The FACED consists of 5 dichotomised variables

Criteria for FACEDClassification of severity
F – FEV1 (≥ 50% = 0 points, < 50% = 2 points)0 – 2 points: Mild bronchiectasis
A – Age (< 70 yrs = 0 points, ≥ 70 years = 2 points3 – 4 points: Moderate Bronchiectasis
C – Chronic colonization (no Pseudomonas = 0 points, presence of Pseudomonas = 1 point)5 – 7 points: Severe Bronchiectasis
E – Extension (1-2 lobes affected = 0 points, > 2 lobes affected = 1 point)
D – Dyspnoea – modified Medical Research Council Scale (mMRC) (0-2 = 0 points, 3-4 = 1 point)

Knowledge of the severity of bronchiectasis can further guide options for both medical and physiotherapy treatment, including the intensity of these treatments.

Many effective treatments are available (and are currently being developed) to help manage bronchiectasis. But it is a condition associated with progressive decline, although the rate of that decline will vary between individuals. A higher frequency of acute exacerbations (flare-ups) are likely to increase the rate of disease progression.


References